Preheat the oven to 325°F with one rack positioned near the top and the other near the bottom. Lightly grease two (15x10-inch) pans with sides using shortening or cooking spray.
Combine oats, pecans, coconut, wheat germ, and sesame seed in a large bowl. In a separate medium bowl, mix butter, honey, brown sugar, vanilla, and salt. Pour the mixture over the oats, stirring until they are evenly coated. Divide the mixture between pans and place one pan on each oven rack.
Bake for 25-30 minutes until golden brown, stirring every 10 minutes and rotating pans halfway through. Cool granola on waxed paper, then mix in cranberries. Store in an airtight container at room temperature for up to 3 days or freeze for up to 6 months.